Turkish Neurosurgery 2018 , Vol 28 , Num 3
Proconvulsant Effect of Papaverine on Penicillin-Induced Epileptiform Activity in Rats
Abdullah Hilmi MARANGOZ1,Sleyman Emre KOCACAN2,Aydin HIM3,Enis KURUOGLU1,Cengiz COKLUK1,Cafer MARANGOZ4
1Ondokuz Mays University, Faculty of Medicine, Department of Neurosurgery, Samsun, Turkey
2Ondokuz Mays University, Faculty of Medicine, Department of Physiology, Samsun, Turkey
3Ondokuz Mays University, Faculty of Medicine, Department of Biophysics, Samsun, Turkey
4Istanbul Medipol University, Faculty of Medicine, Department of Physiology, Istanbul, Turkey
DOI : 10.5137/1019-5149.JTN.19703-17.2 AIM: Papaverine is a vasodilator agent that is an opium alkaloid. It exhibits its effects by inhibiting the phosphodiesterase enzyme. Papaverine administration is widely used to avoid symptomatic vasospasm after subarachnoid hemorrhage. We aimed, in this research, to study the effects of papaverine on the epileptic discharges stimulated by penicillin.

MATERIAL and METHODS: Adult female Wistar rats (22030 g) were included in this research (n=30). Rats were anesthetized with urethane (1.25 g/kg) and then the left cerebral cortex was reached by opening a burr hole with a drill. Penicillin G sodium salt (500 IU)(200 IU/1 ?l) was injected into the left lateral ventricle to produce epileptiform activity. Thirty minutes before penicillin G sodium injection, papaverine was administered at doses of 5, 10, 20 or 40 mg/kg intraperitoneally.

RESULTS: There was no significant difference in spike frequency between the control group and the groups given 5 mg/kg, 10 mg/ kg or 40 mg/kg papaverine, while 20 mg/kg papaverine significantly increased the spike frequency (p<0.05).

CONCLUSION: Papaverine augments the epileptiform activity produced by penicillin injection. It is important to remember that papaverine might induce convulsions in patients who have epilepsy. More research is required to understand the mechanisms of the proconvulsant influence of papaverine in epilepsy. Keywords : Epilepsy, Female rat, Papaverine, Penicillin

Corresponding author : Abdullah Hilmi MARANGOZ, abdyail@yahoo.com