Turkish Neurosurgery 2018 , Vol 28 , Num 6
Neuroprotective Effects of Oleocanthal, a Compound in Virgin Olive Oil, in a Rat Model of Traumatic Brain Injury
Mesut METE1,Isil AYDEMR2,Ulkun UNLU UNSAL3,Fatih COLLU4,Gokhan VATANDAS1,Beyhan GURCU4,Yusuf Kurtulus DURANSOY1,Fatma TANELI5,Mehmet Ibrahim TUGLU6,Mehmet SELCUKI1
1Celal Bayar University, School of Medicine, Department of Neurosurgery, Manisa, Turkey
2Omer Halisdemir University, School of Medicine, Department of Histology and Embryology, Nigde, Turkey
3Koc University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey
4Celal Bayar University, Faculty of Science and Letters, Department of Biology, Zoology Section, Manisa, Turkey
5Celal Bayar University, School of Medicine, Department of Biochemistry, Manisa, Turkey
6Celal Bayar University, School of Medicine, Department of Histology and Embryology, Manisa, Turkey
DOI : 10.5137/1019-5149.JTN.21417-17.2 AIM: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI).

MATERIAL and METHODS: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1 was the sham group (n=5). Group 2 was the trauma group (n=5) where rats were treated with 10 mg/kg saline intraperitoneally (IP) twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n=8) or 30 (group 4, n=8) mg/kg OC IP twice a day. For each group, brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemical methods.

RESULTS: Histopathological evaluation revealed a significant difference between Group 2 and Group 4. Biochemical findings demonstrated that the oxidative stress index was highest in Group 2 and lowest in Group 4.

CONCLUSION: OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress and apoptosis. Keywords : Apoptosis, Neuroprotection, Oleocanthal, Rat, Traumatic brain injury

Corresponding author : Mesut METE, dr.mmete@hotmail.com