Turkish Neurosurgery 2021 , Vol 31 , Num 4
Evaluation of the Neuroprotective Role of Boric Acid in Preventing Traumatic Brain Injury-Mediated Oxidative Stress
Zeki Serdar ATAIZI1,Mete OZKOC2,Gungor KANBAK2,Hadi KARIMKHANI3,Dilek BURUKOGLU DONMEZ4,Novber USTUNISIK2,Buket OZTURK5
1Eskisehir Yunus Emre State Hospital, Department of Neurosurgery, Eskisehir, Turkey
2Eskisehir Osmangazi University, Graduate School of Health Sciences, Department of Medical Biochemistry, Eskisehir, Turkey
3Istanbul Medipol University, Graduate School of Health Sciences, Department of Medical Biochemistry, Istanbul, Turkey
4Eskisehir Osmangazi University, Graduate School of Health Sciences, Department of Medical Histology and Embryology, Eskisehir, Turkey
5Eskisehir Osmangazi University, Faculty of Arts and Sciences, Department of Biology, Eskisehir, Turkey
DOI : 10.5137/1019-5149.JTN.25692-18.4 AIM: To investigate the possible neuroprotective effect of boric acid (BA) by examining the changes in catalase (CAT) activity and levels of CAT and malondialdehyde (MDA) in brain tissues from rats with closed head trauma.

MATERIAL and METHODS: The study consisted of three groups: control, traumatic brain injury (TBI) and TBI + BA. Animals in the control and TBI groups received saline, while animals in the TBI + BA group received BA through daily oral gavage, for 14 days prior to TBI was performed using the modified Marmarou impact acceleration model. After 24 hours, animals were euthanized, and brain tissue obtained to measure the levels of MDA and to assess the activity of CAT.

RESULTS: MDA levels and CAT activity were significantly higher in the TBI group versus the control group. However, they were significantly lower in the TBI + BA group compared to TBI alone. Similarly, edema and necrotic neurons were observed in the TBI group, but not in the control or TBI + BA groups.

CONCLUSION: Based on biochemical and histopathological evidence, we determined that TBI induced lipid peroxidation and oxidative stress were inhibited by pre-treatment with BA. Keywords : Boric acid, Catalase, Malondialdehyde, Oxidative stress, Rat, Traumatic brain injury

Corresponding author : Zeki Serdar ATAIZI, sataizi@gmail.com