Turkish Neurosurgery 2001 , Vol 11 , Num 1-2
EFFECTS OF METHYLPREDNISOLONE ON SERUM NEURON-SPECIFIC ENOLASE LEVELS AF TER GLOBAL ISCHEMIC BRAIN DAMAGE IN RATS
Rüçhan ERGÜN, Gökhan AKDEMİR, Alptekin TASÇI, Önder OKAY, Levent ALBAYRAK, Fikret ERGÜNGÖR
Neurosurgeon, Department of Neurosurgery, Ankara Numune Hospital, Ankara, Turkey Neuron-specific enolase (NSE) is a mitochondriaI enzyme that is found at high levels in neurons. Changes in NSE levels maY provide quantitative information about the extent of certain types of neurological injury, including cerebral infarction, subarachnoid hemorrhage, intracerebral hemorrhage, cınd head trauma. This study investigated serum levels of NSE by enzyme immunoassaY after global cerebral ischemia in rats, and evaluated the effects of low-dose methylprednisolone on serum NSE concentration. The results confirmed that serum NSE is a sensitive marker of cerebral ischemia, and revealed a positive correlation between NSE levels and low-dose methylprednisolone treatment. Keywords : Cerebral ischemia, methylprednisolone, neuron-specific enolase, rat
Corresponding author : Rüçhan Ergün, ruehanergun@hotmail.com