Turkish Neurosurgery 2018 , Vol 28 , Num 5
The Research Progress of Mesenchymal Stem Cells in the Treatment of Traumatic Brain Injury
Gang LI1,Yue YANG1,Hua-jiang DONG1,Ling LIN1
1Tianjin University, State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin, China
2Logistics University of Chinese People?s Armed Police Forces, Tianjin, China
DOI : 10.5137/1019-5149.JTN.20829-17.1 Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in children and adults throughout the world. It is urgent to ameliorate TBI damage and reduce the disability and case-fatality rate. Stem cell therapy is another medical revolution after drug and surgical medication. Mesenchymal stem cells (MSCs) are a class of cells with significant self-renewal and multi-lineage differentiation properties. They are favorable for the treatment of various diseases and injuries. It could be envisioned that MSCs transplantation may be a promising treatment for TBI. Currently, stem cell therapy has shown promising effects in the treatment of many diseases. In this article, we will review the characteristics of MSCs, MSCs for neuronal function restoration, the properties of immune-modulatory of MSCs, and the anti-apoptotic effects of MSCs, the angiogenesis effect of MSCs, and the safety issues in MSCs therapy in TBI. Keywords : Angiogenesis, Anti-apoptosis, Immunomodulatory, Mesenchymal stem cell, Umbilical cord, Traumatic brain injury
Corresponding author : Ling LIN, Hua-Jiang DONG, linling@tju.edu.cn, dhj_424@163.com