Turkish Neurosurgery 1997 , Vol 7 , Num 1-2
THE ROLE OF LYSOPHOSPHATIDIC ACID IN RADIATION INJURY: PILOT STUDY
Murad BAVBEK1, Toshifumi KAMIRYO2, Marcel DURIEUX3
1Baskent University Medical Facu1ty, Department of Neurosurgery, Ankara, Turkey
2New York University Medical Facu1ty, Department of Radiology , New York, USA
3University of Virginia Medical Facu1ty, Department of Anesthesiology, Charlottesville, USA
Lysophosphatidic acid is the simplest phospholipid known. It is produced by platelets, endothelial cells, leukocytes, some cancer cells, astrocytes, and injured fibroblasts. Lysophosphatidic acid is thought to play a role in platelet aggregation and fibrosis. Since in radiation injury, platelet aggregation on endothelial cell surfaces and fibrin formation are the main events, lysophosphatidic acid might play a major role in radiation injury. Keywords : Lysophosphatidic acid, phospholipids, radiation
Corresponding author : Murad Bavbek