Turkish Neurosurgery 2022 , Vol 32 , Num 1
Surgical Treatment in Refractory Epilepsy: Seizure Outcome Results Based on Invasive EEG Monitorization
Zahide MAIL GURKAN1,Nermin Gorkem SIRIN2,Bulent KARA4,Gunay GUL5,Fulya SENGUL EREN5,Betul TEKIN GUVELI5,Sibel VELIOGLU6,Akin SABANCI3,Aydin AYDOSELI3,Yavuz ARAS3,Nerses BEBEK2,Betul BAYKAN2,Altay SENCER3,Ali Tuncay CANBOLAT7,Aysen GOKYIGIT7,Ulger AYDOGAN CULHA7,Candan GURSES8
1Istanbul University, Istanbul Faculty of Medicine, Departments of Neurology and Clinical Neurophysiology, Istanbul, Turkey
2Istanbul University, Istanbul Faculty of Medicine, Department of Neurology, Istanbul, Turkey
3Istanbul University, Istanbul Faculty of Medicine, Department of Neurosurgery, Istanbul, Turkey
4Kocaeli University Faculty of Medicine, Department of Pediatrics, Kocaeli, Turkey
5Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurological Disorders Training and Research Hospital, Departments of Neurology, Istanbul, Turkey
6Karadeniz Technical University, Medical Faculty, Department of Neurology, Trabzon, Turkey
7Self-Employed, Istanbul, Turkey
8Koc University, Faculty of Medicine, Department of Neurology, Istanbul, Turkey
DOI : 10.5137/1019-5149.JTN.32796-20.2 AIM: To discuss seizure outcomes of patients with invasive electroencephalography (EEG) monitorization (IEM) following their epilepsy surgery at our centre.

MATERIAL and METHODS: Forty-seven patients suffering from refractory epilepsy and who were evaluated by invasive EEG were included in this retrospective study at Istanbul Faculty of Medicine from 2003 to 2017. We examined the Video EEG and invasive EEG monitorization, cranial MRI, SPECT, PET and neuropsychological tests of all patients. Postoperative seizure outcome results were evaluated according to Engel classification. The factors affecting seizure outcomes were discussed.

RESULTS: Twenty-six of the patients were female (55.3%), 21 were male (44.7). The average age was 32.0 (± 12.4). Forty-three patients had surgery and the average age of these patients was 26,6 (±11.15). 38.3% of the patients had hippocampal sclerosis (HS), 23.4% had focal cortical dysplasia (FCD), 8.5% had a tumor, 14.9% had sequela lesion and 14.9% had unknown etiology. Postoperative seizure status according to the Engel classification showed that 81.6% of the patients were class I, 10.5% were class II, 2.6% were class III and 5.3% were class IV.

CONCLUSION: A significant relation was statistically determined between structural MRI lesion and favorable seizure outcome (p<0.05). The most frequent etiology was HS in our patients. Of the patients with Engel I, the averages of their ages, ages at onset of epilepsy and ages at surgery were lower than other groups, but the difference was not statistically significant (p>0.05). We argue that IEM is an essential examination for favorable outcomes for determining the epileptogenic zone and/or the proximity of the functional structures. Keywords : Epilepsy surgery, Refractory epilepsy, Invasive EEG monitoring, Outcome, Eloquent cortex

Corresponding author : Zahide MAIL GURKAN, zahidemailgurkan@gmail.com