Issue release date: 08.03.2024
2Zonguldak Bulent Ecevit University, Faculty of Medicine, Department of Neurosurgery, Zonguldak, Turkey
3Sisli Kolan International Hospital, Department of Neurosurgery, Istanbul, Turkey
4Istanbul University, Faculty of Medicine, Department of Veterinary Histology and Embryology, Istanbul, Turkey
5Emsey Hospital, Emsey Advanced Spine Surgery Center, Department of Neurosurgery, Istanbul, Turkey
6Kartal Dr. Lütfi Kirdar Research and Training Hospital, Department of Neurology, Istanbul, Turkey
7Hacettepe University School of Medicine, Department of Neurosurgery, Ankara, Turkey
8GATA Haydarpasa Training Hospital, Department of Neurosurgery, Istanbul, Turkey
9Medipol Mega University Hospital, Department of Neurosurgery, Istanbul, Turkey DOI : 10.5137/1019-5149.JTN.40989-22.2 AIM: To investigate the effects of Contractubex® (Cx) on peripheral nerve regeneration and scar formation.
MATERIAL and METHODS: A surgical procedure involving sciatic nerve incision in 24 adult male Sprague?Dawley rats followed by epineural suturing was performed. In weeks 4 and 12 following surgery, macroscopic, histological, functional, and electromyographic examinations of the sciatic nerve were conducted.
RESULTS: No significant difference was found between the Cx group and the control group in terms of sciatic function index (SFI) and distal latency results at week 4 (p>0.05). However, significant improvements in the Cx group were observed in SFI amplitudes and nerve action potentials at week 12 (p<0.001 and p<0.001, respectively). Significant improvements were found in the amplitudes of nerve action potentials in the treatment group after weeks 4 and 12 (p<0.05 and p<0.001, respectively). Macroscopically and histopathologically, epidural fibrosis decreased (p<0.05 and p<0.001, respectively). For both measurement times, the treatment group had significantly higher numbers of axons (week 4, p<0.05; week 12, p<0.001), and the treatment group had better results regarding its axon area (weeks 4 and 12, p<0.001) and myelin thickness (weeks 4 and 12, p<0.05).
CONCLUSION: Cx, which is applied topically in peripheral nerve injury, affects axonal regeneration and axonal maturation positively and reduces the functional loss.
Keywords : Contractubex, Peripheral nerve, Scarring, Rats