Turkish Neurosurgery 2016 , Vol 26 , Num 6
Biocompatibility of Plastic Clip in Neurocranium - Experimental Study on Dogs
Samir DELIBEGOVIC1,2, Kemal DIZDAREVIC3, Elmir CICKUSIC2,4, Muhamed KATICA5, Muamer OBHODJAS5, Muhamed OCUS6
1University Clinical Center Tuzla, Department of Surgery, Bosnia and Herzegovina
2University of Tuzla, Faculty of Medicine, Bosnia and Herzegovina
3University Medical Center of University of Sarajevo, Neurosurgery Clinic, Bosnia and Herzegovina
4University Clinical Center Tuzla, Laboratory Diagnostics Polyclinic, Bosnia and Herzegovina
5University of Sarajevo, Veterinary Faculty, Bosnia and Herzegovina
6Private Veterinary Ambulance, Uravici, Visoko, Bosnia and Herzegovina
DOI : 10.5137/1019-5149.JTN.13979-15.1 AIM: A potential advantage of the use of the plastic clips in neurosurgery is their property of causing fewer artifacts than titanium clips as assessed by computed tomography and magnetic resonance scans. The biocompatibility of plastic clips was demonstrated in the peritoneal cavity, but their behavior in the neurocranium is not known.

MATERIAL and METHODS: Twelve aggressive stray dogs designated for euthanasia were taken for this experimental study. The animals were divided into two groups. In all cases, after anesthesia, a craniotomy was performed, and after opening the dura, a proximal part titanium clip was placed on the isolated superficial Sylvian vein (a permanent Yasargil FT 746 T clip at a 90? angle, while a plastic Hem-o-lok clip ML was placed on another part of the vein). The first group of animals was sacrificed on the 7th postoperative day and the second group on the 60th postoperative day. Samples of tissue around the clips were taken for a histopathological evaluation.

RESULTS: The plastic clip caused a more intensive tissue reaction than the titanium clip on the 7th postoperative day, but there was no statistical difference. Even on the 60th postoperative day there was no significant difference in tissue reaction between the titanium and plastic clips.

CONCLUSION: These preliminary results confirm the possibility for the use of plastic clips in neurosurgery. Before their use in human neurosurgery, further studies are needed to investigate the long-term effects of the presence of plastic clips in the neurocranium, as well as studies of the aneurysmal model. Keywords : Titanium clips, Plastic clips, Biocompatibility, Neurocranium, Dog

Corresponding author : Samir Del?begov?c, samirdelibey@yahoo.com