Turkish Neurosurgery 2023 , Vol 33 , Num 2
Effect of Adiponectin on Acute Experimental Cerebral Ischemia/Reperfusion Injury
Neslihan ESKUT,Mustafa CETINER,Gonul AKDAG,Fatma AKKOYUN ARIKAN,Hasan Emre AYDIN,Sibel CANBAZ KABAY
1University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Department of Neurology, Izmir, Turkey
2Kutahya Health Sciences University, Faculty of Medicine, Department of Neurology, Kutahya, Turkey
3Kutahya Health Sciences University, Faculty of Medicine, Department of Neurosurgery, Kutahya, Turkey
DOI : 10.5137/1019-5149.JTN.40990-22.2 AIM: To examine the effect of adiponectin administration on acute brain injury in an experimental model of cerebral ischemia/ reperfusion (I/R) in rats.

MATERIAL and METHODS: The study animals were divided into the following four groups: group I, sham (did not undergo surgical intervention and did not receive drugs); group II, the I/R model (received the intervention, but did not receive drugs); group III (I/Radiponectin) (the I/R model was used, and the animals were treated with 5 mg/kg adiponectin peritoneally 30 minutes after the ischemia); and group IV (I/R-tirofiban)( the I/R model was used, and the animals were treated with 0.5 mg/kg tirofiban peritoneally 30 minutes after the ischemia).

RESULTS: Tumor necrosis factor-? (TNF-?) and interleukin (IL)-1? levels were statistically higher in the I/R group (group II) than in other groups. In the post-hoc (Tukey) test analysis, groups I, III, and IV had significantly lower TNF-? and IL-1? levels after treatment with both tirofiban and adiponectin than group II. No statistically significant difference was found between groups III and IV in terms of TNF-? levels. However, the decreased IL-1? level was more pronounced in group IV (tirofiban) than in other groups. The mean neurologic deficit scores were statistically significantly different among the groups. In the post-hoc (Tukey) test analysis, neurologic deficit scores were statistically significantly lower in groups III and IV than in group II.

CONCLUSION: Adiponectin has anti-inflammatory and cerebral protective effects in experimental cerebral I/R injury. Keywords : Rat, Ischemia, Reperfusion, Adiponectin, Tirofiban

Corresponding author : Neslihan ESKUT, nespur@hotmail.com