Issue release date: 08.03.2024
2Bezmialem Vakif University, Department of Pathology, Istanbul, Türkiye
3Bezmialem Vakif University, Department of Radiology, Istanbul, Türkiye
4Bezmialem Vakif University, Department of Biostatistics, Istanbul, Türkiye DOI : 10.5137/1019-5149.JTN.36251-21.4 AIM: To investigate the presence of Sur1-Trpm4 receptors in high-grade glial tumors, and their relationship with edema volumes in preoperative magnetic resonance imaging (MRI) sequences.
MATERIAL and METHODS: MRI sections were extracted from T1-weighted (T1W) and T2-weighted (T2W) sequences and fluidattenuated inversion recovery (FLAIR) images. After that, T1W 3D magnetization-prepared rapid gradient echo (MP-RAGE) sequences were taken with and without contrast medium. Tumor and peritumoral edema volumes were calculated in cubic centimeters. Sur1- Trpm4 receptors were studied by immunohistochemical examination of tissue samples. Relationships between data were analyzed using Spearman?s correlation coefficient.
RESULTS: In the immunohistochemical examinations, 58% of the samples from patients with high-grade glial tumors were positive for Sur1 and 74% were positive for Trpm4. The volume of tumors was correlated with the volume of peritumoral edema.
CONCLUSION: The presence of the Sur1-Trpm4 receptor complex in high-grade glial tumors was confirmed. Further preclinical or clinical studies are required to identify and validate the role of Sur1-Trpm4 in glial tumor subgroups.
Keywords : Brain tumor, Cerebral edema, Glial tumor, Glioblastoma, Sur1-Trpm4