Turkish Neurosurgery 2021 , Vol 31 , Num 3
Chemoresistance in Malignant Intracranial Tumors: Longer Survival with Negative MDR1 Expression
Mehmet Can EZGU1,Cahit KURAL1,Gulcin Guler SIMSEK2,Pinar KAYGIN3, Serpil OGUZTUZUN3,Alparslan KIRIK1,Soner YASAR1,Gulsah KOSE4,Sezen YILMAZ SARIALTIN5, Tulay COBAN5,Oguz KUL6
1University of Health Sciences, Gulhane Education and Research Hospital, Department of Neurosurgery, Ankara, Turkey
2University of Health Sciences, Kecioren Education and Research Hospital, Department of Pathology, Ankara, Turkey
3Kirikkale University, Department of Biology, Kırıkkale, Turkey
4Mugla Sitki Kocman University, Faculty of Health Sciences, Mugla, Turkey
5Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey
6Kirikkale University, Faculty of Veterinary, Department of Pathology, Kırıkkale Turkey
DOI : 10.5137/1019-5149.JTN.29819-20.3 AIM: To analyze the Glutathione S-transferase (GST)-P, GST-M, cytochrome p450 (CYP)1-A1, CYP1-B1, and multidrug resistance (MDR)-1 expressions in malignant intracranial tumor (ICT)s, and to elicit their role on patient survival.

MATERIAL and METHODS: GST-P, GST-M, CYP1-A1, CYP1-B1, and MDR-1 expressions were analyzed using immunostaining in 149 samples from 141 patients with preoperative ICT diagnosis. The case characteristics were reviewed, and the enzyme expressions were equated based on the age, gender, and tumor type. Then, 77 of 141 patients with malignant ICT and complete medical records postoperative were also investigated in detail for the relationship between the diagnosis, enzyme expression, and overall survival.

RESULTS: The average age was 49.44 years, with 83 (58.45%) male patients. Among the 77 malignant ICTs, 38 (49.3%) and 29 were glial tumors and metastases, respectively, with a 13.35-month overall survival. Patients with metastatic tumor have approximately threefold higher GSTP level than those with glial tumors. MDR-1 expression was approximately twofold higher in > 60-year-old patients. No statistically significant association was found between patients? smoking behaviors, alcohol consumption, and overall survival. Only MDR-1 expression was correlated with overall survival. Better overall survival was observed in patients with a negative MDR-1 expression than those with a positive one.

CONCLUSION: MDR-1 is an important indicator of survival in malignant intracranial tumor patients. Longer survival is associated with negative MDR-1 expression. Keywords : Brain, Tumor, Glutathione S-transferase, Cytochrome p450, Multidrug resistance

Corresponding author : Mehmet Can EZGU, mcanezgu@gmail.com